Glucosamine + Chondroitin with MSM, Pure Encapsulations Healthy cartilage strength and resilience Sulfur-containing methylsulfonylmethane (MSM) is included in this glucosamine and chondroitin combination to provide an enhanced spectrum of nutrients for optimal cartilage matrix composition, connective tissue strength, and joint comfort. Glucosamine promotes the synthesis of the glycosaminoglycan chondroitin sulfate. Chondroitin sulfate is responsible for building the ground substance of cartilage, molecules known as proteoglycans. In addition, chondroitin sulfate blocks the action of degradative enzymes. An important role of sulfur from MSM is to enhance the structure and integrity of proteoglycans. Pure Encapsulations Glucosamine and Chondroitin with MSM offers highly purified constituents for healthy cartilage formation and joint movement ease Suggested Use 3 capsules per day, in divided doses, with meals.  Supplement Facts   Container Size 360 Caps   Serving Size 1 Vegi Cap   Amount Per 1 Vegi Cap Content %DV     glucosamine HCl (shellfish), 99% 300 mg   chondroitin sulfate (bovine), 95% 300 mg   MSM (methylsulfonylmethane), 99% 300 mg   vitamin C (as ascorbyl palmitate) 5 mg   % Daily Values (DV) are based on a 2,000 calorie diet. * Daily Value (DV) not established. Product: Glucosamine + Chondroitin with MSM Manufacturer: Pure Encapsulations Item #: GCMS3 Content: 360 Caps