Immun'Age, INTEGRATIVE THERAPEUTICS Immun'Age is a nutritional supplement made from Fermented Papaya Preparation (FPP). Immun'Age is especially formulated to help fight the factors associated with aging, by supporting the body's adaptive systems of oxidation/reduction regulation, immunomodulation, and chelation of harmful metal ions. To date, there are over 30 scientific studies that support its antioxidant, immuno-modulation and metal ion chelation activity. Scientific studies conducted by Professor Lester Packer at the University of California Berkeley, demonstrate Immun'Age's support of the immune and antioxidant systems. Immun'Age has been used in Japan for decades, and its popularity is increasing in Europe. Immun'Age is made from non-GMO Papaya fruits through a natural process called FPP® (Fermented Papaya Preparation). This original process uses no preservatives and follows ISO international quality standards: ISO 9001 for production and ISO 14001 for environmental protection. Immun'Age shows neither side effects nor toxicity when consumed as directed. Immun'Age is well-tolerated and safe to use every day. Supplied in convenient single serve sachets. Key Features of Immun'Age: Over 30 scientific studies to support its antioxidant and immuno-modulation activity Provides antioxidant support Supports the body's immune defenses Helps defend against wrinkles and other signs of aging on the skin Safe for every day use Delicious flavored powder Unique, convenient, single serving sachets HOW DOES IT WORK? The free-radical theory of aging is credited to Denham Harman, MD, PhD, who proposed 50 years ago that aging is the result of accumulated cellular and tissue damage caused by free radicals over one's lifetime. Free radicals (also known as reactive oxygen species) are unstable, highly reactive molecules that have an unpaired electron in their orbit. Free radicals are involved in thousands of reactions in the body that are essential in maintaining life. They play a key role in reproduction, cell maturation and development, cytokine production, and the destruction of toxins. For example, superoxide radicals are generated by neutrophils (white blood cells) during the process of phagocytosis the destruction of harmful bacteria and toxins. Although they are not detrimental in all instances, an overload of free radical activity creates a state of oxidative stress, which can greatly accelerate the aging process. It is for this reason that free radicals are carefully regulated by the body, through means such as the production and activity of key enzymes, including superoxide dismutase (inactivates superoxide radicals), catalase (prevents formation of hydroxyl radicals) and glutathione peroxidase (inactivates hydroxyl radicals and hydrogen perioxde). Free-Radical Regulation Superoxide anion is an active oxygen species instrumental in killing microbes during phagocytosis. In a study performed in Russia, Immun'Age was found to stimulate production of superoxide by neutrophils and macrophages while inhibiting the production of harmful hydroxyl radicals. Such findings suggest that Immun'Age functions not simply as an antioxidant, but as a free-radical regulator. Nitric oxide (NO) is a soluble free radical gas that plays a critical role in immune function and central and peripheral neuronal transmission. In vitro studies observed Immun'Age's interaction with NO and inducible nitric oxide synthase (iNOS). The study showed Immun'Age both scavenged NO and promoted its production in a dose-dependent manner from particular neutrophils and macrophages. Further, in an open randomized controlled clinical trial, researchers observed that administration of Immun'Age supported healthy levels of superoxide, nitric oxide and glutathione in blood monocytes, suggesting once again its antioxidant regulatory properties. Antioxidant Support In human subjects, Immun'Age limited lipid peroxidation caused by oxygen radicals from pulmonary phagocytes. Further it was observed that intake also stimulated antioxidant activities of RBCs and WBCs. In vivo studies demonstrated enhanced levels of glutathione and SOD in erythrocytes and leukocytes after administration of Immun'Age. Immunomodulation Scientific research has shown Immun'Age supports healthy immune function in several ways. Researchers have found increased immune and antioxidant activity in macrophages associated with supplementation of Immun'Age. In vivo studies have shown increased activation of natural killer cell activity. Furthermore, human trials have demonstrated that oral administration of Immun'Age for one month increased the mean rate of gamma interferon production. Among the many actions of interferons is their stimulatory effect on lymphocytes. Immun'Age may induce T-cell and B-cell activity indirectly via increased interferon production. Metal Ion Chelation A scientific study observed Immun'Age to sequester iron salts and scavenge hydrogen peroxide. Further, in a human trial, Immun'Age promoted the excretion of platinum (ingested as part of a therapeutic compound) from the body. Ingredient Benefit Fermented Papaya Preparation (FPP) Promotes healthy antioxidant activity Supports nitric oxide and inducible nitric oxide synthase activity Helps decrease lipid peroxidation Supports production of glutathione and superoxide dismutase Shown to scavenge hydrogen peroxide Supports healthy immune function. Helps increase macrophage activity Supports production of natural killer cells Helps increase interferon production Increases T-cell and B-cell activity Exhibits metal ion chelation activity Chelation of iron salts Chelation of platinum RECOMMENDATIONS Take 1 packet daily or as directed by your physician or professional healthcare provider. Open sachet and empty contents in mouth. Allow contents to dissolve and swallow. Do not take with water. Do not eat or drink anything for 5 minutes before or after taking Immun'Age. Notes: Naturally Processed. No chemicals or preservatives added. Keep in a cool, dry place out of light.  Supplement Facts   Container Size 30 Packets   Serving Size 1 Packet   Amount Per 1 Packet Content %DV     Calories 10   Total Carbohydrate 3 g 1 %   Sugars 3 g *   Fermented Papaya 3 g *     Other Ingredients: yeast, dextrose   Contains No: gluten or ingredients of animal origin   % Daily Values (DV) are based on a 2,000 calorie diet. * Daily Value (DV) not established. Product: Immun'Age Manufacturer: INTEGRATIVE THERAPEUTICS Item #: 56413 Content: 30 Packets